Regarding E2F8, there was no evidence of an association with age, tumor size, lymph node metastasis, or lymph vessel invasion; however, E2F8 expression was significantly associated with histological grade (p = 0.006) and invasion depth of cervical stroma (p = 0.004) (Additional file 1: Table S1). The gene discussed is E2F8; the disease is metastatic malignant neoplasm in the lymph nodes.