E2F2 and metastatic malignant neoplasm in the lymph nodes: Similar to that found for E2F1, upregulated expression of E2F2 was also significantly associated with histological grade (p = 0.003), lymph node metastasis (p = 0.004), lymph vessel invasion (p = 0.014), and invasion depth of cervical stroma (p = 0.002) (Additional file 1: Table S1).