Because expression of E2Fs is associated with multiple clinicopathological factors, including lymph node metastasis, lymph vessel invasion, and depth of invasion of cervical stroma, we further investigated the role of E2F2 and E2F7 in the processes of cell proliferation, migration, and stemness in cervical cancer cells. Here, E2F2 is linked to metastatic malignant neoplasm in the lymph nodes.