The miR-328-3p/HIF1AN-NOTCH2 and miR-892a/HDGF-NCL-PI3K-AKT pathways regulated by circCDYL facilitate Survivin and Myc expression in HCC, suggesting that a combination of circCDYL, HIF1AN and HDGF can be used for the diagnosis of Barcelona Clinic Liver Cancer stage 0 and A of HCC [144]. The gene discussed is NUCLEOLIN; the disease is hepatocellular carcinoma.