As another example, the lncRNA X inactive-specific transcript (XIST) inhibits the proliferation of HCC cells through the miR-497-5p/PDCD4 or miR-92b/Smad7 pathway, but promotes HCC progression by silencing miR-194-5p and derepressing MAPK1 [92–94]. This evidence concerns the gene SMAD7 and hepatocellular carcinoma.