In addition, CD4+ or CD8+ T cells labeled with CFSC were also detected using flow cytometry (Fig. 1h), which revealed that, compared with mice treated with antagomir NC, MDSCs in the peripheral blood and tumor tissues of mice injected with miR-21 antagomir markedly reduced the inhibition of Th and CTL proliferation (p < 0.05) (Fig. 1i, j). This evidence concerns the gene CD8A and neoplasm.