And we found LINC00346 might play a vital role in the carcinogenesis of PC through regulating interleukin signaling, cell cycle checkpoints, cell proliferation, DNA damage stimulus, PLK1 signaling pathway, HIF-1-αtranscription factor network, p53 signaling pathway, etc. (Additional file 1: Figure S1C, Additional file 2: S2C). This evidence concerns the gene PRECSIT and pachyonychia congenita.