The pathway enrichment for these four lncRNAs revealed that all of them might play an important role in the chronic and smoldering inflammation in the tumor microenvironment (TME) of PC, perhaps leading to the hypoxia or hyaluronan-induced development of desmoplastic stoma, deactivation of anti-tumor immune cells (e.g. CD8+ T cells, CD4+ T cell, and NK cells), recruitment of anti-inflammatory immune cells (e.g. macrophages M2 and neutrophils) (Additional file 2: Figure. This evidence concerns the gene CD4 and pachyonychia congenita.