IL1B and colitis: Because of the chronic inflammatory reaction and excess cytokine secretion that are associated with UC, IL-1β, IL-6, TNF-α, and PGE2 levels were assessed in colon mucosa as well as the mRNA expression of Mapk14. As illustrated in Figure 6, prominent rises in levels of TNF-α (Figure 6(a)), IL-1β (Figure 6(b)), IL-6 (Figure 6(c)), and PGE2 (Figure 6(d)) were detected in experimental colitis group along with significant upregulation in the mRNA expression of Mapk14 (Figure 6(e)) in the experimental colitis group compared to the control group.