Elevated circulating serum YKL-40 levels have been noted in many pathological conditions, such as acute and chronic inflammation, cancer, liver fibrosis in nonalcoholic fatty liver disease, insulin resistance, obesity, endothelial dysfunction, atherosclerosis, and even cardiovascular disease (CVD) [1–9]. This evidence concerns the gene CHI3L1 and obesity due to melanocortin 4 receptor deficiency.