Second, we explored the association of serum Fetuin-B with IR using multiple intervention experiments, including a euglycemic-hyperinsulinemic clamp (EHC, euglycemic-hyperinsulinemic state), an oral glucose tolerance test (OGTT) (elevated blood glucose and insulin levels), or liraglutide, a glucagon-like peptide-1 receptor agonists (GLP-1RA) treatment (from insulin-resistant to insulin-sensitizing state) in healthy controls and/or women with PCOS. The gene discussed is GLP1R; the disease is polycystic ovary syndrome.