Importantly, in response to increased insulin levels, serum Fetuin-B concentrations were markedly increased in PCOS females from 6.40 ± 0.75 to 8.52 ± 0.89 mg/L during the clamp (p < 0.05 vs. 0 min, Figure 1(c)). This evidence concerns the gene INS and polycystic ovary syndrome.