The results of ELISA confirmed that the levels of cytokines such as TNF-α, IL-1α, IL-10, IL-6, HMGB1, and sCD14 in septic rats increased significantly, indicating that the intrinsic immunity and adaptive immunity were activated; proinflammation and anti-inflammation coexisted in the early stage of sepsis [25]; CD4+CD25+Treg and TH17 simultaneously increased, and the ratio of Treg/TH17 decreased also confirmed that immune activation and suppression were accompanied by each other, but immune activation dominated at the early stage of sepsis. This evidence concerns the gene IL1A and Sepsis.