Moreover, CDKAL1 seems to be associated with Crohn's disease (CD) 42 and psoriasis 43 (where low levels of CDKAL1 were present in the colon, small intestine, and skin-keratinocytes (Fig. 2) 24), but the CDKAL1 SNP associated with T2D does not confer susceptibility to psoriasis or CD 24, 44. Here, CDKAL1 is linked to type 2 diabetes mellitus.