Further mechanism disclosed that lnc-MCEI functioned as a competing endogenous RNA (ceRNA) via sponging miR-6759-5p and lnc-MCEI mediated the chemosensitivity of ESCC by targeting miR-6759-5p/IGF2/PI3K/AKT axis. This evidence concerns the gene AKT1 and esophageal squamous cell carcinoma.