Preischemic hyperglycemia further augmented the alteration as reflected by the higher levels of Fis1 and Drp1 in hyperglycemic animals at 6h of reperfusion than those observed in the normoglycemic counterparts, suggesting that hyperglycemia caused an early onset of mitochondrial fission process by hyperglycemia. The gene discussed is DNM1L; the disease is Hyperglycemia.