Consistent with these results, transfecting a HIF-1α plasmid into SNHG11 knockdown cells strikingly eliminated the suppressive influence caused by SNHG11 knockdown on CRC cell migration and invasion (Fig. 5C, D), suggesting that SNHG11-mediated HIF-1α upregulation contributes to the promotion of SNHG11 on CRC cell migration and invasion. This evidence concerns the gene HIF1A and colorectal carcinoma.