DSH rats had a progressive increase in urinary albumin levels (Fig. 1d–f) and showed marked albuminuria compared with the DSN group at 4 weeks (DSH, 11.15 ± 1.40 mg/day versus DSN, 0.61 ± 0.08 mg/day; P < 0.001; Fig. 1f). This evidence concerns the gene ALB and Charcot-Marie-Tooth disease type 3.