We observed that proteins of the in vitro-derived ACT response network have high clinical relevance, for example TNNC1, TNNT2, TPM1, MYH7, MYL2, FLNC, MYBPC3, and NEBL genetic variants have been strongly associated with dilated cardiomyopathies as shown in a recent review40 (Supplementary Fig. 17). This evidence concerns the gene TPM1 and dilated cardiomyopathy.