IL17A and psoriasis: However, anti-IL-17A antibody-treated PD-1−/− mice showed more severe IMQ-induced psoriasis-like dermatitis than IgG Ctrl-treated WT mice, as evaluated by PASI score (4.8 ± 0.8 vs. 3.6 ± 0.5, P = 0.003 by two-way ANOVA) and ear swelling (7.4 ± 1.6 μm vs. 5.2 ± 1.4 μm, P = 0.053 by two-way ANOVA) at day 5 (Supplemental Fig. 5B).