Furthermore, our analysis of human samples from anti-PD-1 antibody-treated cancer patients revealed that the serum level of sIL-6 presented correlates with that of sIL-6Rα in patients with anti-PD-1 antibody-induced psoriasis-like dermatitis, which would result in enhanced epidermal infiltration of CD8 T cells. Here, CD8A is linked to skin disorder.