While the regulatory roles of RhoE have been almost entirely linked to cell actin cytoskeleton dynamics, cell migration, and apoptosis in its early studies9–13, we have uncovered versatile functions of RhoE in intracellular Ca2+ homeostasis regulation14, apoptosis15, angiogenesis16, inflammation17, brain development18, and glioblastoma genesis19,20 along with other groups21–24. Here, RND3 is linked to glioblastoma.