Albumin represents the nutritional condition of the human body and peripheral blood lymphocyte is an important immune index, the unbalance of albumin and lymphocyte is closely correlated with poor post-operative complications and cancer outcomes which have already demonstrated by multiple cancer types such as liver cancer6, non-small cell lung cancer7, bladder cancer4, pancreatic cancer8,9, colorectal cancer10, esophageal cancer11–13, ovarian cancer14, and renal cell carcinoma15. The gene discussed is ALB; the disease is cancer.