Moreover, high concentrations of IL-6 were found specifically in several ocular diseases, such as secondary glaucoma, PEX syndrome, surface ocular and intraocular inflammation, MO, CRVO, BRVO, PVR, ROP and RD, but not to POAG, PACG, AMD, CNV, asymptomatic CL users, pachychoroid spectrum diseases, ERM, cataract, pseudophakia and PBK (summarized in Fig. 8). The gene discussed is IL6; the disease is open-angle glaucoma.