In the BMSCNumb-KD group with HQD treatment, although liver fibrosis has improved compared with the BMSCNumb-KD group, Hyp content and the mRNA levels of α-SMA, TGF-β1, TNF-α, ColI,CK7 and CK19 were significantly increased compared to that in the HQD group, suggesting that BMSCNumb-KD transplantation into the liver promotes CLF by reducing Numb expression, thereby weakening the effect of HQD against CLF. The gene discussed is NUMB; the disease is Hepatic fibrosis.