CLU and obesity due to melanocortin 4 receptor deficiency: To investigate the role of increased clusterin in diet-induced obesity and NAFLD, we generated transgenic mice with whole-body clusterin overexpression (wCLU-tg; C56BL/6J-CLUfloxed+/+ × C56BL/6JElla cre+) and confirmed that clusterin upregulation has a protective effect.