SRI and Huntington disease: Since Sorcin is known to be overexpressed in substantia nigra of PD patients39,40, and the release of high amount of dopamine from substantia nigra pars compacta is one of the most important early features of HD54, we explored the expression of Sorcin in the same brain region of the most commonly used murine model of HD (caused by an autosomal dominant CAG expansion mutation of the huntingtin gene) vs. control mice.