Sorcin expression is increased significantly in cortex of HD patients stage 2/4, 3/4 and 4/4 of disease progression with respect to control cortices (Figs. 6A and S10); Sorcin is particularly upregulated (+99 ± 42%, p < 0.01) in patients at stage 2/4 (early intermediate stage), almost fully functional, indicating that it may represent an early marker of neurodegeneration. This evidence concerns the gene SRI and Huntington disease.