We measured Sorcin expression in different neurodegenerative disease models, in order to assess whether Sorcin is overexpressed in these models and is able to respond to ER stress in the brain; in particular, we studied Sorcin expression in different phases of neurodegeneration, to understand whether Sorcin is particularly expressed in the early phases of neurodegenerative diseases and whether it may represent an early marker of neurodegeneration. Here, SRI is linked to neurodegenerative disease.