Further, Sorcin is more expressed in the frontal cortex of asymptomatic AD patients with respect to symptomatic AD patients35, and is more expressed in amyloid plaques in sporadic vs. rapidly progressive AD patients, and in AD vs. cerebral amyloid angiopathy patients36,37, thereby possibly protecting from acceleration progression that takes place in the aggressive forms of the disease. This evidence concerns the gene SRI and Alzheimer disease.