Often neuronal cells have dysregulated Ca2+ homeostasis and express low concentration of calcium buffering proteins, when aging and/or hit by neurodegenerative diseases and are more prone to undergo ER stress60,61; in turn, Sorcin is highly expressed in the brain, and is further overexpressed in human, mice and cellular neurodegenerative diseases models, and is, therefore, an important player in the calcium-linked mechanisms at the basis of neurodegeneration. The gene discussed is SRI; the disease is neurodegenerative disease.