Since Sorcin is able to interact and regulate important players in these events, and it is highly expressed in brain, and further overexpressed in neurodegenerative diseases models, especially as an early stress marker, luminescence-based measurements of cytosolic and ER calcium transients were carried out both in HeLa cells and in a brain-derived tumor cell line (SH-SY5Y) to evaluate Sorcin-dependent Ca2+ cellular regulations. The gene discussed is SRI; the disease is neurodegenerative disease.