PSEN2 and Alzheimer disease: Sorcin is able to bind and regulate Cav1 channels (voltage-operated calcium channel, VOC), interacts with the N-methyl-D-aspartate receptor (NMDAR) and with RyR in caudate-putamen nucleus, and regulates Na+–Ca2+ exchanger (NCX); in addition, it interacts in a calcium-dependent fashion with αSyn and presenilin 2 (PS2), proteins involved in calcium homeostasis and in PD and AD pathogenesis, respectively.