INS and diabetes mellitus: The second is a disease-related group, in which higher values of the host factors or increased cadence of lifestyle behaviors are generally associated with worse overall health, including BMI; diabetes markers (e.g., HOMA − IR, Insulin, glucose, HbA1c); cardiovascular risk factors (e.g., LDL cholesterol, triglycerides, and blood pressure); inflammation risk markers (e.g., CRP − HS, IL − 6); and poor digestion symptoms (e.g., diarrhea, acid reflux).