SERPINE1 and endothelial dysfunction: Among the emergent interchromosomal interactions in dysfunctional ECs, we identified an interaction involving a SE on chromosome 2 overlapping LINC00607 (a long intergenic noncoding RNA with unknown function), and a SE on chromosome 7 overlapping SERPINE1/PAI-1 (plasminogen activator inhibitor, a crucial regulator in endothelial dysfunction and many vascular diseases)16.