Compared to the other 29 genes embedded in the 12 Linc607SE-interacting SEs, again SERPINE1 ranked first by odds ratio in both cultured ECs and donor-derived ECs (diamond dots, Fig. 5b, c), revealing another level of consistence of diabetes-associated single-cell transcriptomes with that of our in vitro model. This evidence concerns the gene SERPINE1 and diabetes mellitus.