Also, since NKX2-2 and NKX3-1 binding sites are similar, since NKX2-2 is critical for the beta-cell phenotype, and is abundant in both normal beta cells and insulinomas, it is possible that the predicted NKX3-1 binding sites may also serve as NKX2-2 binding sites. Here, NKX2-2 is linked to pancreatic insulinoma.