In addition, the log2 3× increase in NFATC1 expression in insulinomas vs. beta cells, together with the hypomethylation of the multiple NFATC1 binding sites in the SYT8/TNNI2 region, suggests that insulin gene transactivation in insulinoma may employ transcriptional signals derived from NFATC1. This evidence concerns the gene NFATC1 and pancreatic insulinoma.