Thus, although most insulinomas had mutations in different genes, 90% displayed variants in members of the Trithorax Group (TrxG) (exemplified by MEN1, KDM6A, MLL3/KMT2C), the Polycomb Repressive Complex (PRC) (exemplified by EZH2, YY1, H3F3A) or related epigenetic modifiers (exemplified by KDM5B, KMT2C, SMARCC1). Here, KDM6A is linked to pancreatic insulinoma.