Whether NFaTs preferentially bind in insulinomas—as compared to beta cells—to distal 11p15.5-p.15.4 sites, as suggested by the model in Fig. 7b, and whether this alters INS expression and regional 3D chromatin structure, as the model may predict, also will be of great interest to decipher in future studies. The gene discussed is INS; the disease is pancreatic insulinoma.