INS and pancreatic insulinoma: Using elegant 4C-Seq approaches in the EndoC-βH1 human beta-cell line, Jian and Felsenfeld13 showed that the anchor makes frequent contacts with a region centromeric to the INS/IGF2 locus that overlaps with our hypermethylated dark red region and contains the majority of the PDX1 binding sites, which are hypermethylated in insulinomas.