Using elegant 4C-Seq approaches in the EndoC-βH1 human beta-cell line, Jian and Felsenfeld13 showed that the anchor makes frequent contacts with a region centromeric to the INS/IGF2 locus that overlaps with our hypermethylated dark red region and contains the majority of the PDX1 binding sites, which are hypermethylated in insulinomas. This evidence concerns the gene IGF2 and pancreatic insulinoma.