Thus, it was of great interest to observe that expression of NFATC1 is increased by a factor of three-fold in insulinomas and that other NFaT family members are altered10, and that its cognate response elements at the telomeric end of 11p15.5-p15.4 target sub-region are hypomethylated, and therefore presumably accessible to the NFaT family. This evidence concerns the gene NFATC1 and pancreatic insulinoma.