KCNQ1OT1 and pancreatic insulinoma: In 2016, Bhatti et al.28 described similar methylation patterns in 9 insulinomas occurring in children across 3 CpG dinucleotides of the H19/IGF2 ICR; in addition, hypomethylation was detected across 3 CpG dinucleotides of the kvDMR1 ICR (a.k.a. ICR2).