Uncovering the precise role of PRMT5/Wnt4/β-catenin in the progression of laryngeal carcinoma will not only increase our knowledge of PRMT5-induced tumorigenesis, but also accelerate the development of novel biomarkers and therapeutic strategies for laryngeal carcinoma patients with lymphatic metastasis. The gene discussed is PRMT5; the disease is laryngeal carcinoma.