PRMT5 and laryngeal carcinoma: To elucidate the effect of PRMT5 on the migration and mobility of laryngeal carcinoma cells, we performed in vitro wound-healing and Transwell assay, and found that PRMT5 overexpression increased migration and invasion of Tu212 cells, while PRMT5 knockdown in Tu686 cells had the opposite effect (Fig. 3a, b).