To gain further insight into PRMT5-mediated cancer metastasis and invasion, we investigate the downstream signaling pathway responsible for PRMT5-mediated tumor growth and metastasis, at least partly, attributed to Wnt4-increased β-catenin nuclear translocation; the induction of β-catenin signaling is critical for the proliferation and migration29. This evidence concerns the gene WNT4 and neoplasm.