ECM-associated proteins include several anticoagulant proteins (e.g. the annexin family members ANXA3, ANXA4, ANXA5, and ANXA8L1) of ECM-affiliated proteins were markedly diminished (Fig. 4d), which is consistent with the results indicating coagulation dysfunction in the COVID-19 patients (Figs. 2 and 4a). The gene discussed is ANXA4; the disease is COVID-19.