GATA6 and cholangiocarcinoma: Then, we screened the GATA6-enriched genes and finally focused on a new potential candidate, MUC1, based on the following evidence: (i) MUC1 is a glycoprotein that induces metastasis and the EMT in cancers21–23; (ii) overexpression of MUC1 promotes metastasis in CCA24; and (iii) our ChIP-Seq data showed that GATA6 was enriched in the MUC1 promoter region in CCA cells (Fig. 2a).