ATM and neoplasm: Nutrition management is an important part of comprehensive therapy for cancer patients.25,26 Metabolic reprogramming has been suggested to be a major characteristic and contributor of malignancies.27–29 Emerging studies indicate that metabolic reprogramming of immune cells can also regulate antitumor immunity.30–33 Given that ATM activity can be regulated by HFD consumption,17,34 we presumed that HFD treatment might be a potential strategy for the modulation of the tumor microenvironment in CRC-PC, a disease with limited intervention strategies.