BMP4 and neural tube defect: As shown in Table 1 and Fig. 7e, 21 out of 87 embryos without BMP4 Tg expression (non-BMP4 Tg) from diabetic dams had NTDs (NTD rate was 24.14%), whereas embryos with or non-BMP4 Tg from nondiabetic dams did not exhibit any NTDs.