ACE and Alzheimer disease: Interestingly, several studies have established a link between RAS-targeting anti-hypertensive drugs, such as angiotensin converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs), and AD (Ohrui et al., 2004; Davies et al., 2011; Abdalla et al., 2013; Qiu et al., 2013; Yasar et al., 2013; de Oliveira et al., 2014; Wharton et al., 2015).