CD274 and cancer: Antitumor response with nivolumab was independent of PD-L1 status, while clinically meaningful efficacy with pembrolizumab was observed in CPS ≥10.25 Overall, these results were comparable with reports of ICIs combination treatment in patients with advanced or recurrent G/GEJ cancer,26–28 and were similar to those previously reported for ramucirumab plus paclitaxel,10 which suggest that HX008 plus irinotecan may be a promising therapeutic option as second-line therapy.