Therefore, the psychological condition of GBM patients should be taken into consideration in our future clinical work, and the targeted therapy towards LTBP1 might be a promising research direction for our future clinical and experimental research, which may further provide us with a shared mechanism for both GBM and depressive/anxiety disorders, as well as a possible precise treatment for GBM patients showed the symptom of depression and anxiety disorders. Here, LTBP1 is linked to anxiety disorder.