In order to further compare this relation, GBM patients were firstly divided into groups “High” and “Low”, which stand for those with higher and lower PHQ-9 or GAD-7 score than mild level, respectively; There are 19 patients who gained both higher score of PHQ-9 and GAD-7; while 25 patients gained lower scores of both the two scales (Additional file 3: Figure S1a). Here, GAD1 is linked to glioblastoma.