Next, Daisong et al. used scRNA-seq to discover unidentified protein C receptor-positive (Procr+) cell populations in the pancreas and used lineage analysis to show that these cells can differentiate into endocrine cells; in addition, Procr+ pancreatic organoids transplanted into a mouse model of diabetes regulated blood sugar and secreted insulin, thereby ameliorating diabetes [102] (Fig. 5a). Here, PROCR is linked to diabetes mellitus.