IL6 and neoplasm: Indeed, TME cells also promote resistance to antitumor therapies, since the secretion of soluble factors such as interleukin-6 (IL-6), hepatocyte growth factor (HGF), fibroblast growth factor (FGF), or transforming growth factor ß (TGF-ß) and ECM adhesion proteins such as integrins leads to the activation of several tumor survival pathways [19].