In addition, tumor-secreted HIF-1 induces miR-155 expression under hypoxic conditions and plays a dual role in maintaining this factor as miR-155 directly targets HIF-1 and suppresses its expression and miR-155 suppresses the translation of von Hippel–Lindau tumor suppressor (VHL) leading to increased HIF activity. The gene discussed is VHL; the disease is neoplasm.