In previous studies, overexpression of SIRT1 has been shown to ameliorate DMD pathophysiology in mdx mice [69], while salermide inhibition of SIRT1 has been shown to protect muscle cells against oculopharyngeal muscular dystrophy in Caenorhabditis elegans [70]. This evidence concerns the gene SIRT1 and oculopharyngeal muscular dystrophy.