In methylation-based surrogates of plasma proteins and smoking pack-years, PAI1 (18346.47 for control and 19880.95 for MetS, p < 0.001) and TIMP1 (34309.52 for control and 34686.02 for MetS, p =0.004), in MetS, respectively, were significantly higher than controls. This evidence concerns the gene SERPINE1 and metabolic syndrome.