As previously reported in larger series [24, 25], we found heterogeneous genomic profiles, with few recurrent molecular aberrations, including mutations of TP53 and PIK3CA and copy number gains MYC, CCND1, FGF19, FGF3, and FGFR1. Specific alterations were significantly associated with breast cancer subtypes in both primary tumors and recurrences. The gene discussed is TP53; the disease is breast cancer.