For example, separate categories have been created based on the presence of alterations such as isocitrate dehydrogenase-wild type 1/2 (IDH1/2) [8]⁠ and histone 3 mutations, which are frequently found in adult low-grade and pediatric high-grade gliomas, respectively [9, 10]⁠. Here, IDH1 is linked to glioma.