They show partial overlap with previously described IDH-WT glioma subcategories using other profiling strategies, such as PA-like astrocytomas [43]⁠ identified from the methylation data and which possess a transcriptomic profile similar to pilocytic astrocytomas of the posterior fossa, uncommon IDH-WT gliomas [17]⁠ identified by cluster of cluster analysis of four data types (mRNA, miRNA, methylation, copy number variation), and molecularly lower-grade gliomas [44]⁠ which are IDH-WT gliomas lacking one of these alterations: EGFR amplification, H3F3A, and pTERT mutations. The gene discussed is IDH1; the disease is pilocytic astrocytoma.