To address the potential role of COX-1 in RP progression, we backcrossed COX-1 knockout mice (COX-1−/−) onto rd10 mice, a well-characterized mouse model of RP [17, 18], and investigated the impact of COX-1 deletion on neuroinflammation in the resulting COX-1−/−/rd10 mouse line. Here, PTGS1 is linked to retinitis pigmentosa 1.