IL6 and Autoimmunity: Furthermore, the reversion of Il6 expression in different cells using this IL6-DIO-KO mouse model, combined with cell-specific Cre transgenic lines, would be key to elucidate the specific functions of IL-6 from each cellular source and study cell-specific IL-6 targeting strategies in EAE and a wide range of autoimmune and neuroinflammatory diseases.