The histological analysis of the upper part of the spinal cord (segments C1–T11) from MOG-IL6-DIO-KO mice revealed a decrease of demyelination and limited invasion of CD3+ in the white matter, as previously observed using other IL-6 KO models immunized with MOG35-55 [11, 12], and highlighting once again a critical role of IL-6 in the prototypical autoimmune disorder. This evidence concerns the gene IL6 and Autoimmunity.