Based on these findings, 4 additional HAEnCI types were defined: HAE with a specific mutation in the PLG gene (HAE-PLG), HAE with a specific mutation in the ANGPT1 gene (HAE-ANGPT1), HAE with a specific mutation in the KNG1 gene (HAE-KNG1), and HAE with a specific mutation in the MYOF gene (HAE-Myoferlin). Here, ANGPT1 is linked to hereditary angioedema.