In bladder cancer cells, m6A-modified direct targets IKBKB and RELA (two key regulators of the NF-κB pathway) mediated by METTL3 become factors that promote tumour development [13]; in glioblastoma stem cells (GSCs), knocking down METTL3 can induce changes in m6A-enriched mRNA and alter the mRNA expression of genes with key biological functions in GSCs (such as ADAM1937) [41]. The gene discussed is IKBKB; the disease is glioblastoma.