Using multivariate Cox regression analysis in the 70 patients with advanced-stage disease, METTL3 expression in tumour cells (HR: 6.725, P = 0.010) was an independent prognostic factor for DFS, while METTL3 expression in tumour cells (HR: 5.140, P = 0.021) and CD33+ MDSCs (HR: 8.802, P = 0.037) were independent prognostic factors for OS (Table 4). The gene discussed is CD33; the disease is neoplasm.