Furthermore, other reports have highlighted that patients with optimal low levels of serum A. actinomycetemcomitans IgG and IgA titers may represent a good chanced having better gingival health conditions associated with low levels of interleukin (IL)-1β and IL-10, tissue-destruction mediators during PT and coronary diseases [40–43]. The gene discussed is IL1B; the disease is coronary artery disorder.