Considering the interaction among lncRNA SNHG14, HOXB13 and miR-133a in A549/DDP cells, we further investigated whether miR-133a is involved in the process of lncRNA SNHG14 regulating the DDP-resistance of NSCLC through HOXB13 pathway. This evidence concerns the gene HOXB13 and non-small cell lung carcinoma.