Based on the significance of individual markers [25, 29, 35, 36], it is hypothesized that in non-metastatic GaC, cancers with negative expression of both markers may be relatively weak in both local growth and nodal metastasis capacities, cancers with positive Ki-67 expression but negative Her2 expression may have a stronger local growth potential, tumors with positive Her2 expression but negative Ki-67 expression may be more prone to invasion and nodal metastasis, and tumors with positive expression of both markers may be strong in both capacities. This evidence concerns the gene ERBB2 and cancer.