When fed WDF, MS-NASH mice develop NAFLD/NASH phenotypes with elevation of plasma ALT/AST and lipid as early as 4 weeks, an increase in liver triglycerides ~ 12 weeks, and exhibition of hepatic steatosis, ballooning, inflammation and mild to moderate fibrosis ~ 20 weeks [22]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.