GPT and obesity due to melanocortin 4 receptor deficiency: Similar to the previous report in MS-NASH mice [22], the present data confirmed that compared to the control diet (CD), WDF enhanced the obesity phenotype (Fig. 1a) with reduction in food (Fig. 1b), but not caloric (Fig. 1c) intake, and significantly elevated serum ALT (Fig. 1d) and AST (Fig. 1e).