TNF and tuberculosis: A heatmap representation of the TruC results illustrates 10 proteins with higher responses (IFNγ, IL-18, IL-1RA, IL-2, IL-6, IL-8, chemokine (C-C motif) ligand [CCL3], CCL4, tumor necrosis factor α [TNFα]) and 2 with lower responses (CCL11, factor VII) in active TB as compared with patients with LTBI (Figure 2A), with no discernible pattern observed in the QFT stimulations for these cytokines (Figure 2B).