While our studies indicate that global deletion of Nox4 did not alter intestinal fibrosis in mice, inducing kidney fibrosis by unilateral ureteral obstruction (UUO) or cardiac interstitial fibrosis by chronic pressure overload revealed protective effects of Nox4 in murine fibrogenesis [[59], [60], [61], [62]]. The gene discussed is NOX4; the disease is Interstitial cardiac fibrosis.