AGTR1 and stroke disorder: Interestingly, although the brain RAS plays an important role in regulation of systemic BP and AT2R signalling can oppose vasoconstrictive AT1R signalling, AT2R agonism by CGP4112 or C21 does not affect BP when the agonist is delivered before [262] or after [261,267] MCAO either by systemic [264], intracerebral [260] or intranasal [271] delivery nor after embolic stroke [273].