However, 12% of cases carried rs71542416 but were negative for HLA-DRB1∗10:01, suggesting that the SNP may be a tag for other rare HLA alleles, which is consistent with the hypothesis of Heap et al21 who showed an association between HLA-DQA1-HLA-DRB1 variants and thiopurine-induced pancreatitis. This evidence concerns the gene HLA-DQA1 and pancreatitis.